Figure 7.
Effect of CBDA (0.02, 0.1, 0.5 mg·kg−1) or VEH administered i.p. to shrews 45 min prior to the application of motion. The number of emetic episodes (A) and latency of onset to the first emetic episode (B) induced by a 10 min horizontal motion stimulus (frequency: 1 Hz; amplitude: 40 mm) was measured in shrews. Each bar represents the mean ± SEM, n = 5–15. The asterisks indicate a significant difference from the VEH-treated control animals analysed using one-way anova followed by Dunnett's post hoc test (*P < 0.05; **P < 0.01; ***P < 0.001).