Table 4. Stratified analysis of LMP2 gene codon 60 genotypes with chronic HCV infection.
Stratified characteristics | Persistent infection [n (%)] |
Spontaneous clearance [n (%)] |
Controls [n (%)] |
Controls/Persistent infection OR(95%CI)* |
Controls/Spontaneous clearance OR(95%CI)* |
Persistent infection/Spontaneous clearance OR(95%CI)* |
||||||
Arg/Arg | Arg/His +His/His | Arg/Arg | Arg/His +His/His | Arg/Arg | Arg/His +His/His | Arg/Arg | Arg/His +His/His | Arg/Arg | Arg/His +His/His | Arg/Arg | Arg/His +His/His | |
Age (y) | ||||||||||||
≤30 | 38(67.9) | 18(32.1) | 52(63.4) | 30(36.6) | 63(60.0) | 42(40.0) | 1.00 | 0.83(0.38-1.82) | 1.00 | 1.15(0.56-2.36) | 1.00 | 0.81(0.39-1.68) |
>30 | 74(63.2) | 43(36.8) | 61(57.0) | 46(43.0) | 77(64.2) | 43(35.8) | 1.00 | 0.83(0.45-1.54) | 1.00 | 0.97(0.51-1.85) | 1.00 | 0.73(0.42-1.26) |
Gender | ||||||||||||
male | 79(64.2) | 44(35.8) | 76(60.3) | 50(39.7) | 95(60.5) | 62(39.5) | 1.00 | 0.87(0.49-1.55) | 1.00 | 0.90(0.50-1.60) | 1.00 | 0.80(0.47-1.35) |
female | 33(66.0) | 17(34.0) | 37(58.7) | 26(41.3) | 45(66.2) | 23(33.8) | 1.00 | 0.65(0.26-1.62) | 1.00 | 1.25(0.53-2.97) | 1.00 | 0.67(0.30-1.49) |
IDU | ||||||||||||
yes | 91(66.4) | 46(33.6) | 95(59.0) | 66(41.0) | 42(57.5) | 31(42.5) | 1.00 | 0.68(0.37-1.26) | 1.00 | 1.04(0.59-1.84) | 1.00 | 0.67(0.41-1.09) |
no | 21(58.3) | 15(41.7) | 18(54.3) | 10(35.7) | 98(64.5) | 54(35.5) | 1.00 | 1.09(0.50-2.37) | 1.00 | 0.91(0.38-2.16) | 1.00 | 1.24(0.43-3.59) |
Duration of drug use (y) | ||||||||||||
≤5 | 48(81.4) | 11(18.6) | 46(59.7) | 31(40.3) | 95(61.3) | 60(38.7) | 1.00 | 0.25(0.11-0.59) | 1.00 | 0.74(0.38-1.46) | 1.00 | 0.35(0.16-0.78) |
5∼10 | 32(54.2) | 27(45.8) | 53(66.2) | 27(33.8) | 26(59.1) | 18(40.9) | 1.00 | 1.52(0.63-3.66) | 1.00 | 0.84(0.35-2.00) | 1.00 | 1.73(0.82-3.64) |
≥10 | 32(58.2) | 23(41.8) | 14(43.8) | 18(56.2) | 19(73.1) | 7(26.9) | 1.00 | 2.26(0.76-6.76) | 1.00 | 2.76(0.81-9.39) | 1.00 | 0.54(0.22-1.34) |
* Logistic regression model, adjusted by gender, age, injection drug user, and duration of drug use.