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. 2013 Feb 19;9(3):228–236. doi: 10.7150/ijbs.5476

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© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.

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Malformed tooth root development in OC-Cre;Ctnnb1^fl/fl mice. Sirus red-stained sections of the mandible first molars (A, B, E and F) and the longitudinal sections of incisors (C, D, G and H) from Ctnnb1^fl/fl and OC-Cre;Ctnnb1^fl/fl mice at P15 (A-D) and P45 (E-H). (a-h) The higher-magnification views of the boxed areas in A-H, respectively. Blue arrows point to the dentin while asterisks denote the periodontal collagen fibrils. On sections from OC-Cre;Ctnnb1^fl/fl teeth, black arrows indicate calcified tissues that were probably deposited by the dysplastic cell bearing Ctnnb1 deficiency. D, dentin; DP, dental pulp; OD(r), root odontoblast; OD(li), lingual odontoblast. Scale bar: 100μm (A-H), 25μm (a-h).