Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2013 Feb 19;9(3):228–236. doi: 10.7150/ijbs.5476

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.

PMC Copyright notice

Disruption of β-catenin in odontoblasts and cementoblasts disrupts their differentiation in OC-Cre;Ctnnb1^fl/flmice. ISH analyses show the expression of Col1a1 (A-D), OC (E-H), Dspp (I-L), and Bsp (M-P) on sections of molars and incisors from P15 Ctnnb1^fl/fl and OC-Cre;Ctnnb1^fl/flmice. (a-p) The images are higher-magnification views of the boxed areas in the top. In OC-Cre;Ctnnb1^fl/fl sections, blue arrows indicate the dysplastic cells beneath the tooth crown and labial incisor that were absent of differential markers for an odontoblastic linage. Red asterisks show that cells lining the calcified tissues were positive for Col1a1, OC and Bsp expression but negative for Dspp expression. Black arrows in m-p demonstrate that cementoblasts labeled by Bsp signals were missing within the periodontium of OC-Cre;Ctnnb1^fl/flteeth. DP, dental pulp; OD(c), crown odontoblast; OD(r), root odontoblast; OD(li), lingual odontoblast; PDL, periodontal ligament; AB, alveolar bone; Ce, cementoblast. Scale bar: 50μm (A-P, top), 20μm (a-p).