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. 2013 Feb 19;9(3):228–236. doi: 10.7150/ijbs.5476

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© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.

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Absence of β-catenin in odontoblasts impedes their proliferation. (A, B) Double-immunofluorescence of BrdU (red) and K14 (green) performed on sections of the mandible first molars from P8 Ctnnb1^fl/fl and OC-Cre;Ctnnb1^fl/flmice. (C) Quantification of BrdU-positive pre-odontoblasts on sections of the mandible first molars from P8, P11 and P15 Ctnnb1^fl/fl and OC-Cre;Ctnnb1^fl/flmice. Yellow arrows indicate that BrdU-positive pre-odontoblasts in OC-Cre;Ctnnb1^fl/fl molars were reduced. White arrows indicate the HERS. D, dentin; DP, dental pulp; OD(r), root odontoblast. Scale bar: 60μm (A and B). Results represent the arithmetic means ± SEM of results for four mice per group. *, P < 0.05.