Table II.
Blocking IL-6R does not affect the frequency of T cells, B cells or monocytesa.
| 0 m | 1 m | 3 m | 6 m | cp | |
|---|---|---|---|---|---|
| CD4 T cells | 38.6 (9.2) | 40.6 (12.1) | 42.4 (8.7) | 41.5 (6.5) | 0.56 |
| bCD45RA | 32.8 (10.9) | 31.3 (11.8) | 31.0 (12.2) | 42.6 (9.9) | 0.69 |
| bCD45RO | 47.5 (12.9) | 43.1 (11.2) | 43.4 (10.9) | 42.6 (10.7) | 0.10 |
| B cells | 6.1 (4.6) | 5.3 (3.1) | 5.0 (3.0) | 5.9 (4.3) | 0.27 |
| Monocytes | 15.7 (8.3) | 14.3 (8.7) | 13.3 (7.6) | 11.3 (8.8) | 0.76 |
aPercentage of the total CD4 T cells, B cells and monocytes in PBMC. Mean (n=8) and standard deviation (in parenthesis) are provided. bPercentage of CD45RA cells and CD45RO cells within the CD4 T cell population. Mean (n=8) and standard deviation (in parenthesis) are provided. cThe significance of the difference in percentage over time was determined by single-group repeated measures analysis of variance based on ranked data. p value less than 0.05 was considered significant.