Table 4. Prevalence of GJB2, GJB3, GJB6, and SLC26A4 genes and mtDNA 12SrRNA A1555G mutation in the Chinese population.
Different areas of China | Patients (n) | Frequency of pathologic variants(%) |
References | ||||
12SrRNA A1555G | GJB2 | GJB3 | GJB6 | SLC26A4 | |||
Northern China | 743 | 2.92 | 18.12 | - | - | 18.15 | Yu Fei et al.2006[25] |
Liu Xin et al.2006[26] | |||||||
Song RD et al.2007[27] | |||||||
Zhu QW et al.2007[28] | |||||||
Zhu YH et al.2008[29] | |||||||
Northeastern China | 377 | 1.00 | 20.80 | - | - | - | Yu Fei et al.2006[25] |
Liu Xin et al.2006[26] | |||||||
Chen JX et al.2007[30] | |||||||
Wang Ping et al.2001[31] | |||||||
Eastern China | 135 | 1.50 | 35.55 | 0 | 3.70 | 15.56 | This study |
Southern China | 404 | 2.70 | 10.80 | - | - | - | Yu Fei et al.2006[25] |
Liu Xin et al.2006[26] | |||||||
Northwestern China | 1639 | 4.10 | 17.61 | 2.20 | 0 | 12.85 | Dai Pu et al.2006[32] |
Guan Jing et al.2006[33] | |||||||
Yu Fei et al.2006[25] | |||||||
Liu Xin et al.2006[26] | |||||||
Yuan YY et al.2008[34] | |||||||
Guo YF et al.2008[35] | |||||||
Du RL et al.2009[36] | |||||||
Southeastern China | 140 | - | 40.00 | - | - | - | Wang SH et al.2009[37] |
Others | 533 | - | 20.70 | 3.70 | 0.30 | 12.38 | Li QZ et al.2005[38] |
Han DY et al.2006[39] | |||||||
Li Qi et al.2007[40] | |||||||
Yuan YY et al.2007[41] | |||||||
Sun Qing et al.2008[18] | |||||||
Average value | 2.44 | 23.37 | 1.97 | 1.33 | 14.74 | 43.57% (total) |