Figure 3. Effects of amphetamine on dopamine content of striatal vesicles Mice were treated with (+)-amphetamine (10 mg/kg i.p.), sacrificed after 1 h, and striata were dissected for vesicle isolation.

Plotted are normalized frequency histograms of vesicular data for amphetamine-treated mice (blue) versus untreated mice (gray). The distribution means were 2.9 zmol^1/3 and 3.7 zmol^1/3, for the amphetamine and untreated vesicles, respectively. Data plotted as the cube root transform. Bin size = 0.2 zmol^1/3. Fits were obtained from a Gaussian distribution of the data.