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An overview of the pre-mRNA splicing process (left panel, adapted from Kramer [60]). The structure and function of proteins involved in mammalian pre-mRNA splicing [60] and a representation of the SF3b subunit (right panel, adapted from Kotake et al [20]). The target for FR901464, pladienolide B, E7107, spliceostatin and sudemycin is the SF3b subunit.
Abbreviations: BP: xxx; PSF: xxx; SR: xxx.[RE3]
