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. 2013 Jan 11;121(11):1986–1994. doi: 10.1182/blood-2012-05-433755

Figure 4.

Figure 4

Disease conditions of lupus correlate with HSPC mobilization and lineage biased hematopoietic output. (A) Each symbol represents the number of LSK cells in the spleen of each mouse of indicated groups. (B) CFU assays were performed to evaluate relative frequencies of clonogenic HSPCs in total splenocytes of mice for indicated groups. Each symbol represents the value of 1 mouse. (C) Each symbol displays the absolute number of B220+ cells in the BM of mice for indicated groups. (D) Each symbol displays the absolute number of Gr1+ cells in the BM of mice for indicated groups. (E) Dot plots show fluorescence-activated cell sorting analysis of myeloid progenitors. The absolute numbers of GMPs in each mouse of indicated groups are shown by each symbol. *P < .05; ***P < .001. B6-O, old B6 mice at 10 months of age; B6-Y, young B6 mice at 8 to 10 weeks of age; TC-H, healthy TC mice at 8 to 10 weeks of age; TC-L, lupus TC mice at 10 months of age.