Table 1.
Histamine receptor inhibitors | Serotonin receptor inhibitors | |||
---|---|---|---|---|
Assay | Inhibition | No inhibition | Inhibition | No inhibition |
3H thymidine incorporation | H1; H2 | H4 | 5-HT2; 5-HT3 | 5-HT1, 6,7 |
Transwell migration | H4 | H1; H2 | 5-HT2; 5-HT3 | 5-HT1, 6,7 |
Wound-healing migration | H1; H4 | H2 | 5-HT1, 6, 7; 5-HT3 | 5-HT2 |
Tube formation | H1; H2; H4 | - - | 5-HT2; 5-HT3 | 5-HT1, 6,7 |
Angiogenesis in vivo | H1; H2 | H4 | 5-HT2; 5-HT3 | 5-HT1, 6,7 |
SU1489, an inhibitor of VEGFR-2, fully inhibited VEGF-A stimulation, but not that of histamine or serotonin, in all of the above assays.