Table 2.
Regional Values in Healthy Brain and in Pathologies From the Literature, With N Denoting the Number of Participants
| Region | Reference | N = | DKI imaging parameters | Voxel size | MK | RK | MD [μm2/ms] | RD [μm2/ms] | FA |
|---|---|---|---|---|---|---|---|---|---|
| Healthy brain | |||||||||
| Internal capsule | [5] | 20 | 32 directions, 2 b-values (1000, 2000 ms/μm2) | 2 × 2 × 3 mm3 | 1.21 ± 0.04 | 1.86 ± 0.10 | 0.84 ± 0.03 | 0.51 ± 0.04 | 0.60 ± 0.03 |
| [1] | 4 | 15 directions 6 b-values (0, 500, 1000, 1500, 2000, 2500 ms/μm2) | 2 × 2 × 2 mm3 | 1.05 ± 0.08 | 0.84 ± 0.03 | ||||
| Corpus callosum | [5] | 20 | 1.14 ± 0.05 | 2.25 ± 0.23 | 0.95 ± 0.03 | 0.47 ± 0.03 | 0.70 ± 0.02 | ||
| Thalamus | [5] | 20 | 0.82 ± 0.03 | 0.93 ± 0.04 | 0.86 ± 0.03 | 0.76 ± 0.03 | 0.24 ± 0.02 | ||
| [1] | 4 | 0.93 ± 0.03 | 0.92 ± 0.13 | ||||||
| [7] | 4 | 30 directions 6 b-values (0, 500, 1000, 1500, 2000, 2500 ms/μm2) | 2.5 × 2.5 × 2.5 mm3 | 0.84 ± 0.02 | 0.95 ± 0.03 | 0.27 ± 0.02 | |||
| Putamen | [5] | 20 | 0.79 ± 0.04 | 0.83 ± 0.6 | 0.81 ± 0.04 | 0.76 ± 0.03 | 0.12 ± 0.01 | ||
| [29] | 30 | 3 directions, 41 b-values (0 to 4000 ms/μm2 in 100 ms/μm2 steps) | 2 × 2 × 5 mm3 | 0.71 | |||||
| Pathologies | |||||||||
| Glioma grade II | [20] | 0.48 ± 0.02 | 1.67 ± 0.2 | 0.12 ± 0.01 | |||||
| [30], LGG | 11 | b values 700, 1000, and 2800 ms/μm2, in 25, 40 and 75 directions, respectively | 2.5 × 2.5 × 2.5 mm3 | 0.47 | 0.49 | 1.53 | 0.13 | ||
| Glioma grade III | [20] | 13 | 0.62 ± 0.03 | 1.46 ± 0.07 | 0.14 ± 0.01 | ||||
| Glioma grade IV | [20] | 16 | 0.81 ± 0.04 | 1.11 ± 0.06 | 0.20 ± 0.03 | ||||
| [30], HGG | 17 | 0.60 | 0.65 | 1.43 | 0.15 | ||||
| Subacute ischemia | [21], WM | 1 | 15 directions | 2 × 2 × 3 mm3 | 1.33 | 0.33 | |||
| GM | 16 b-values with bmax = 7500 s/mm2 | 0.66 | 0.52 | ||||||
| Putamen (Parkinson) | [29] | 30 | 0.93 ± 0.15 | ||||||