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. 2013 Apr 1;140(7):1424–1432. doi: 10.1242/dev.089599

Fig. 4.

Fig. 4.

Sox2 expression localizes to dental lamina and successional dental lamina during continuous tooth replacement in five reptile species. (A-O) Localization of Sox2 protein (brown) in American alligator [embryonic stages (Es) 19-24] (A-D), green iguana (juvenile) (E-G), leopard gecko (post-hatching juvenile) (H-J), 60-day post-oviposition ball python (K-M) and 30-day post-oviposition corn snake (N,O). Arrows in alligator and iguana point to Sox2 expression in the lingual dental epithelium (A,B,C,F). Note that there is no lingual asymmetry in Sox2 expression in snakes (L,N). Sox2 expression is absent from the free end of the successional dental lamina (asterisks) in all species except gecko. Staining in the deposited enamel in gecko is non-specific (I, arrowhead). Boxed areas in K represent higher magnifications in L and M. Dashed lines outline the dental epithelium. 1°, first generation tooth; 2°, second generation tooth; dl, dental lamina; OEE, outer enamel epithelium; sl, successional dental lamina. Scale bars: 100 μm.