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. 2013 Jan 11;6(2):323–331. doi: 10.1242/dmm.009977

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© 2013. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.

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Fig. 4. — Percentage stenosis, ratio of lipid core to lesion area, fibrous cap thickness and percentage of class IV and class V lesions in stressed and unstressed mice of different ages. (A) Percentage stenosis increases with age from 16 to 20 weeks (P<0.01). At 16 weeks, stressed animals had greater percentage stenosis than unstressed animals (*P=0.02). (B) Ratio of lipid core to lesion area increases with age (P<0.01). (C) Fibrous cap thickness decreases with age (P=0.02). There is a trend for thinner fibrous cap in stressed animals (P=0.05). At 16 weeks, only one non-stressed mouse had a fibrous cap. (D) Percentage of class IV and V lesions increases with stress in 16-week-old mice (*P=0.02) and with age from 16 to 20 weeks (**P=0.01). Complex atheroma (class V) increases significantly with stress at the age of 20 weeks (#, P=0.03); however, there are significantly less complex atheroma (class V) in the 40-week-old mice compared with 20-week-old mice (##, P<0.01). All stressed animals at 20 weeks (100%) had class IV or V lesions.