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. 2012 Oct 12;6(2):434–442. doi: 10.1242/dmm.010645

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© 2013. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.

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Fig. 4. — Endolymphatic duct and sac of Atp6v0a4 mutants is abnormally expanded. (A-F) H&E staining of sections at E16.5 (A,B) and P0 (C-F). Mutant mice show a clear expansion of the endolymphatic duct and sac at E16.5 (A,B) and in newborn mice (C-F). Higher magnification at P0 (E,F) shows an abnormal enlargement of the endolymphatic duct and sac in mutants (F) without the typical infolded epithelium seen in the wild types (E). ED, endolymphatic duct; CO, cochlea. Scale bars: (A-D) 300 μm; (E,F) 200 μm.