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. 2012 Sep 11;6(2):503–507. doi: 10.1242/dmm.010587

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© 2013. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.

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Fig. 2. — Rearing in hypoxia or activation of cardiac HIF signalling retards postnatal maturation of cardiac conduction. (A-H) Wild-type neonates reared in 10% oxygen for the first 24 hours after birth show decreased heart rate (A) and increased QTc (B), QRS duration (C) and QTc dispersion (D) compared with normoxic controls (n=9). A similar trend was noted in αMHC-Cre::VHL^fl/fl mice (VHL-mut), which upregulate cardiac HIF signalling constitutively, but not in heterozygote αMHC-Cre::VHL^fl/+ (VHL-het) or αMHC-Cre littermates (cre) (E,F,G,H). Means ± s.e.m. are shown.