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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Nat Struct Mol Biol. 2013 Jan 27;20(3):380–386. doi: 10.1038/nsmb.2487

Figure 5.

Figure 5

Conformational differences between AfC3PO Trax-like and Translin-like subunits. (a) Superposition of AfC3PO Trax-like and Translin-like subunit ‘catalytic sites’. The Trax-like subunit catalytic site is colored as in Fig. 2c with the RNA omitted (yellow side chains, orange and grey subunits, green metal). The Translin-like subunit ‘catalytic sites’ are colored with green side chains, pink and blue subunits, and pink metals. The superposition is of the four (independent) sites from one half of the AfC3PO octamer (one Trax-like, three Translin-like). Red arrows show notable side chains shifts, caused by altered positioning of the adjacent (grey or blue) subunits. (b) Views illustrating a concerted conformational switch adjacent to the ‘catalytic sites’ of Trax-like (left) and Translin-like (right, × 3 superimposed) subunits. Boxes highlight residues participating in the conformational switch, illustrated by black arrows.