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. 2012 Jun 30;26(6):448–455. doi: 10.7555/JBR.26.20110114

Fig. 1. Sinomenine inhibits iNOS mRNA and protein expression in the spinal cord of EAE rats.

Fig. 1

Rats from the sinomenine-treated and control groups (n = 6 per group) were sacrificed on d 4 post onset. The mRNA and protein levels of iNOS in the spinal cord were quantified by RT-PCR (A) and immunoblotting (B). The results shown are mean±SD. for three independent experiments. A statistical evaluation was performed to compare the experimental groups and corresponding controls. *P < 0.05. CON: control group treated with incomplete Freund's adjuvant (IFA) supplemented with Mycobacterium tuberculosis emulsified with 0.2% DMSO plus pertussis toxin; experimental autoimmune encephalomyelitis (EAE) rats treated with 0.2% DMSO; SIN 50: EAE rats treated with 50 mg/kg sinomenine; SIN100: EAE rats treated with 100 mg/kg sinomenine; SIN200: EAE rats treated with 200 mg/kg sinomenine.