Table 3.

Reported and reconstructed effect sizes for trends in prognostic markers of HIV-1 infection.

	Linear regression reported adjusted (unadjusted)		Linear regression on medians unadjusted weighted by n		Linear regression on medians unadjusted not weighted		Quantile regression on medians unadjusted not weighted		Linear regression reported adjusted (unadjusted)
CD4+ T-cell counts	cells/µl per year	s.e.	cells/µl per year	s.e.	cells/µl per year	s.e	cells/µl per year	s.e.	Transformed CD4	s.e.
Galaia[7]	4.20 (4.30)	6.40 (6.30)	3.75	8.66	0.45	7.39	−1.67	11.94	NA
Sinicco et al.b[15]			−11.25	13.34	−10.23	14.29	−15.96	22.34	NA
Easterbrook et al.b[4]			3.2	4.09	4.14	3.93	3.33	6.37	log; 0.01 (0.001)	0.01 (0.01)
Dorrucci et al. [16]	−7.3 (−8.60)	2.1 (2.0)	−13.71	1.37	−13.3	1.34	−13.85	2.8	NA
Müller et al.c[10]	−1.85 (−2.22)	0.96 (0.56)	−1.11	1.9	−0.13	1.6	0.93	3.89	Slope;−0.66 (NA)	0.84 (NA)
Dorrucci et al. [18]	−6.61 (−6.33)	1.07 (1.06)	−5.8	0.79	−5.43	0.74	−6.11	1.55	NA
Herbeck et al. [11]	−7.9 (−7.7)	4.35 (3.48)	−7.12	2.2	−5.41	3.86	−2	6.8	sqrt;−0.15 (−0.14)	0.07 (0.08)
Crum-Cianflone et al.b,d[22]			−7.63	3.08	−7.24	3.01	NA		ref; −101.5 (−118)	20.7 (15.6)
Gras et al. [20]			−4.69	1.32	−4.67	2.34	−5.63	3.1	cbrt;−0.03 (−0.03)	0.01 (0.01)
Müller et al.e[21]	−5.91 (−11.9)	0.86 (0.57)	−11.07	2.63	−14.3	2.44	−9.5	6.17	Slope;−1.69 (−2.0)	0.30 (0.35)
Potard et al. [23]	−5.76 (−6.28)	2.76 (2.72)	−6.71	0.89	−6.88	0.87	−6.83	2.61	NA	NA
Troude et al.b[12]			−5.08	3.55	−6.69	3.39	−5.5	6.13	sqrt;−0.01 (−0.07)	NA

	Linear regression reported adjusted (unadjusted)		Linear regression on means unadjusted weighted by n		Linear regression on means unadjusted not weighted
Set point viral loads	log10 copies/ml per year	s.e.	log10 copies/ml per year	s.e.	log10 copies/ml per year	s.e.
Müller et al.c[10]	0.012 (0.016)	0.006 (0.004)	0.016	0.007	0.016	0.007
Dorrucci et al. [18]	0.035 (0.044)	0.007 (0.005)	0.045	0.011	0.044	0.01
Herbeck et al. [11]	−0.005	0.012	0.015	0.01	0.018	0.019
Crum-Cianflone et al.b[22]			0.000	0.007	1.60E-03	0.005
Gras et al.a[20]			0.016	0.007	0.023	0.01
Müller et al.e[21]	−0.013 (−0.006)	0.005 (0.004)	−0.006	0.005	0.003	0.008
Potard et al. [23]	NA (0.056)	NA (0.014)	0.03f	0.02	0.033f	0.019
Troude et al. [12]	0.01 (0.015)	NA	0.013f	0.006	0.014f	0.007

Effect sizes and standard errors in grey boxes were used for meta-analysis. ACS, Amsterdam Cohort Studies on HIV Infection and AIDS; ATHENA, AIDS Therapy Evaluation in the Netherlands Cohort; cbrt, cube root; MASTER, Italian MASTER Cohort; ref, reference; s.e., standard error; SHCS, Swiss HIV Cohort Study; sqrt, square root.

^aData shared by ATHENA and ACS for calculation of linear regression slope (effect size).

^bData extracted from published manuscript for calculation of linear regression slope (effect size).

^cpdated estimate from analysis of additional unpublished data from the SHCS.

^dMean values used.

^eUpdated estimate from analysis of additional unpublished data from the MASTER cohort.

^fMedian values used.