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Tissue-specific knockdown of Aldolase expression via RNAi causes reduced lifespan and neurodegeneration. (A) Expression of Aldolase-RNAi in neurons (C155-Gal4) or (B) glia (MIB-Gal4) severely reduces lifespan. (C) Expression of Aldolase-RNAi in neurons does not cause overt neuropathology, whereas expression in glia but not neurons (D), elicits neuropathology in the optic lobes, which in some cases can be very severe.
