Table 1.
Ocular tissue homogenate inter day precision validation results, quality control each (n = 6 of 1 of 3 batches).
LLOQC) (2.3 ng/mL) | LQC (10 ng/mL) | MQC (480 ng/mL) | HQC (800 ng/mL) | |
---|---|---|---|---|
Cornea | ||||
Mean concentration (ng/mL) | 2.1 | 10.7 | 499.0 | 829.0 |
Inter run % CV | 10.3 | 8.5 | 5.7 | 1.8 |
Inter run % Bias | −10.9 | 6.8 | 3.9 | 3.6 |
Iris ciliary body | ||||
Mean concentration (ng/mL) | 2.0 | 10.3 | 472.1 | 847.4 |
Inter run % CV | 10.9 | 3.8 | 2.0 | 2.8 |
Inter run % Bias | −15.2 | 2.9 | −1.6 | 5.9 |
Lens | ||||
Mean concentration (ng/mL) | 2.1 | 9.8 | 562.1 | 807.4 |
Inter run % CV | 17.2 | 7.9 | 1.0 | 4.0 |
Inter run % Bias | −10.9 | −2.2 | −3.7 | 0.9 |
Aqueous humor | ||||
Mean concentration (ng/mL) | 2.0 | 10.3 | 494.7 | 824.2 |
Inter run % CV | 7.1 | 4.0 | 4.6 | 3.0 |
Inter run % bias | −13.0 | 2.8 | 3.1 | 3.0 |
Sclera | ||||
Mean concentration (ng/mL) | 2.2 | 9.7 | 432.1 | 797.4 |
Inter run % CV | 9.9 | 8.2 | 10.9 | 2.3 |
Inter run % bias | −6.5 | −3.3 | −10.0 | −0.3 |
Vitreous humor | ||||
Mean concentration (ng/mL) | 2.6 | 10.2 | 452.1 | 825.4 |
Inter run % CV | 0.0 | 11.1 | 16.7 | 2.6 |
Inter run % bias | 13.0 | 2.4 | −5.8 | 3.2 |
Retina choroid | ||||
Mean concentration (ng/mL) | 2.4 | 9.5 | 409.6 | 840.4 |
Inter run % CV | 15.0 | 14.0 | 3.7 | 0.0 |
Inter run % bias | 2.2 | −4.9 | −14.7 | 5.0 |
LLOQC: lower limit of quality control; LQC: low quality control; MQC: middle quality control; HQC: high quality control.