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. Author manuscript; available in PMC: 2013 Dec 14.
Published in final edited form as: Mol Cell. 2012 Dec 14;48(5):665–666. doi: 10.1016/j.molcel.2012.11.027

Figure 1. Nup98 Regulates the Stability of Selected p53-Induced mRNAs and Possibly Suppresses Tumorigenesis.

Figure 1

In response to genotoxic stimuli, the tumor suppressor protein p53 upregulates target genes such as p21 to regulate the cell cycle and DNA repair. In normal cells, the interaction of Nup98 with the 3′UTR of p21 mRNA protects p21 from degradation. In the absence of Nup98, the exposed p21 mRNA is targeted for exosome-mediated degradation. Singer et al. (2012) showed that downregulation of Nup98 expression occurs in some types of cancer, which may lead to destabilization of selected p53 target mRNAs, contributing to tumorigenesis.