Table 1.
Results before bronchoalveolar lavage at 3 hours and 5 hours after surfactant treatment in twelve rabbits
| Variable | Synsurf group (n = 4) | Exosurf group (n = 4) | Exosurf + Ca2+ group (n = 4) |
|---|---|---|---|
| Weight (kg) | 3.13 ± 0.56 | 2.95 ± 0.19 | 3.44 ± 0.24 |
| Pre-VT (mL/kg) | 10.08 ± 0.29 | 10.20 ± 0.58 | 10.03 ± 0.35 |
| 180 minutes | 10.08 ± 0.17 | 9.85 ± 0.21 | 10.13 ± 0.19 |
| 300 minutes | 10.05 ± 0.10 | 9.75 ± 0.24 | 9.93 ± 0.22 |
| Pre-MABP (mmHg) | 82.60 ± 4.07 | 92.40 ± 3.83 | 91.50 ± 7.51 |
| 180 minutes | 89.50 ± 11.21 | 100.30 ± 6.99 | 93.25 ± 4.72 |
| 300 minutes | 87.00 ± 15.12 | 96.75 ± 12.2 | 91.00 ± 14.67 |
| Pre-PaO2 (mmHg) | 499.70 ± 9.46 | 511.10 ± 17.38 | 509.30 ± 24.08 |
| Post- | 57.95 ± 14.90 | 53.25 ± 15.97 | 50.81 ± 18.30 |
| 180 minutes | 152.30 ± 49.27 | 85.69 ± 25.85 | 109.90 ± 46.32 |
| 300 minutes | 281.30 ± 47.64 | 74.25 ± 8.84 | 85.69 ± 32.56 |
| Pre-a/A ratio | 0.76 ± 0.02 | 0.77 ± 0.04 | 0.76 ± 0.03 |
| Post- | 0.09 ± 0.02 | 0.08 ± 0.02 | 0.08 ± 0.03 |
| 180 minutes | 0.23 ± 0.07 | 0.13 ± 0.04 | 0.16 ± 0.07 |
| 300 minutes | 0.42 ± 0.07 | 0.11 ± 0.01 | 0.13 ± 0.05 |
| Pre-PaCO2 (mmHg) | 40.69 ± 3.15 | 39.38 ± 6.26 | 36.19 ± 8.04 |
| 180 minutes | 38.44 ± 4.99 | 38.63 ± 5.49 | 36.19 ± 4.99 |
| 300 minutes | 36.75 ± 2.12 | 40.13 ± 4.18 | 38.81 ± 7.15 |
| Pre-PetCO2 (mmHg) | 14.25 ± 3.06 | 14.63 ± 3.09 | 13.88 ± 1.3 |
| 180 minutes | 9.56 ± 1.88 | 10.13 ± 2.17 | 10.69 ± 0.94 |
| 300 minutes | 9.75 ± 1.50 | 9.38 ± 1.44 | 9.75 ± 2.21 |
| Pre-P(a-et)CO2 (mmHg) | 26.44 ± 4.95 | 24.75 ± 6.15 | 22. 31 ± 7.07 |
| Postlavage | 43.50 ± 15.16 | 42.66 ± 8.67 | 42.88 ± 15.07 |
| 300 minutes | 27.00 ± 2.60 | 30.75 ± 3.06 | 29.06 ± 8.58 |
| Cdyn (mL/cm H2O/kg) | |||
| Prelavage | 0.93 ± 0.16 | 0.98 ± 0.16 | 0.88 ± 0.17 |
| Postlavage | 0.47 ± 0.04 | 0.46 ± 0.05 | 0.42 ± 0.06 |
| 300 minutes | 0.47 ± 0.01 | 0.42 ± 0.02 | 0.44 ± 0.06 |
| Rawe | |||
| Prelavage | 33.75 ± 3.59 | 45.25 ± 24.06 | 36.75 ± 11.03 |
| Postlavage | 53.50 ± 4.20 | 74.25 ± 25.93 | 59.25 ± 13.07 |
| 300 minutes | 46.75 ± 11.33 | 72.00 ± 22.32 | 55.25 ± 9.85 |
Note: Data are shown as the means ± standard deviation.
Abbreviations: VT, tidal volume; MABP, mean arterial blood pressure; PaO2, arterial PO2; PAO2, alveolar PO2; PaCO2, arterial PCO2; PetCO2, end-tidal PCO2; P(a-et) CO2, arterial end-tidal PCO2; Rawe, expiratory airway resistance; Cdyn, dynamic respiratory compliance; a/A ratio, arterial/alveolar ratio.