Table 1.
Multiplicity of infection and severity of malaria
| Mean multiplicity of infection (MOI) | ||||
|---|---|---|---|---|
| Number of isolates | ||||
| Site (reference) | Genotypic marker | Uncomplicated malariaa | Severe malariab | P value |
| Gambia (Conway et al. 1991) | msp1, msp2 | 2.04 (118) | 2.11(35) | >0.05 |
| Senegal (Roberts et al. 1996) | msp1, msp2, glurp, csp, hrp1 | 3.1 (30) | 2.2 (56) | <0.05 |
| Gabon (Kun et al. 1998)c | msp1, msp2 | NR (100) | NR (100) | >0.05 |
| Ghana (Nielsen et al. 2002) | msp1, msp2, glurp | 2.1 (28) | 2.0 (34) | >0.18 |
| India (Ranjit et al. 2005)d | msp1, msp2, glurp, hrp1 | NR (40) | NR (35) | <0.001 |
| Gabon (Mayengue et al. 2007) | msp1, msp2 | 2.9 (30) | 3.0 (30) | >0.05 |
| Sudan (A-Elbasit et al. 2007) | msp2 | 1.53 (103) | 1.5 (106) | >0.05 |
| Nigeria (Amodu et al. 2008) | msp2 | 2.1 (144) | 1.4 (131) | <0.05 |
| Madagascar (Durand et al. 2008) | msp2 | 3.72 (134) | 3.73 (102) | >0.05 |
| India (Rout et al. 2009) | msp1, msp2 | 2.5 (48) | 3.1 (48) | 0.002 |
NR indicates not reported.
aUM, uncomplicated malaria is defined as acute falciparum malaria in the absence of danger signs or evidence of severe malaria
bSM, severe malaria denotes cerebral malaria, severe malarial anaemia, respiratory distress, prostration, hypoglycaemia or other (World Health Organization 1990, 2000) criteria defining severe malaria.
cSevere malaria cases comprised of severe malarial anaemia (haemoglobin < 5 g/dl) and hyperparasitaemic cases; mild malaria cases included for haemoglobin levels >8 g/dl.
dSevere malarial anaemia defined as haemoglobin < 7gm/dl; association of multiple allele frequency only significant for the msp2 allele.