Figure 2.

Specific [³H]PBR28 binding in dorsolateral prefrontal cortex (DLPFC) from schizophrenia patients (SZ) and healthy controls (HC) with (A) and without (B) stratification based on genotype. (A) Using a one-way analysis of variance (ANOVA), specific binding in the high-affinity state (HH) group was statistically significant as follows: *P<0.001 versus heterozygous (HL) and low-affinity state (LL) SZ, and P=0.007 versus HH HC. **P<0.001 versus HL and LL HC, ^†P<0.001 versus LL HC. (B) The distribution of specific binding for HH and HL subjects shown in this panel would mimic positron emission tomography (PET) imaging results in living patients, after our typical exclusion of LL subjects. One-way ANOVA resulted in nonsignificant differences between HC and SZ groups (P=0.085). When genotype was added to the statistical model as a fixed factor; however, SZ patients had significantly greater specific binding than HC subjects (P=0.011).