Figure 6.

(A) Effects on proliferation by addition of lipoprotein. HK1-EBER and -vector cells cultured in serum-free culture medium only or culture medium and lipoprotein were subjected to MTS assay. Cells exhibited lipoprotein-dependent proliferation. Bars are the average of three independent experiments and Y-error bars represent SEM. P<0.05, % of viable cells in lipoprotein-supplemented culture medium vs. culture medium without lipoprotein. (B) Effect of blockade of LDLR-ligand interaction by anti-human LDLR antibody on LDL-induced proliferation. Cell proliferation was not induced by the addition of lipoprotein following inhibition of LDLR-ligand interaction. P>0.05, cells with unsupplemented vs. lipoprotein-supplemented culture medium. Bars are the average of three independent experiments and Y-error bars represent SEM. EBERs, Epstein-Barr virus-encoded RNAs; LDLR, low-density lipoprotein receptor; SEM, standard error of mean.