Table II.
The mortality and clinical signs of animals following injection with Taxol and Lipusu in the acute toxicity study.
| Drug | Formulation (paclitaxel, mg/kg) | Animals/group | Mortalities/group | Mortality ratio (%) | Clinical signs |
|---|---|---|---|---|---|
| Lipusu | 96.8 | 10 | 8 | 80 | Asthenia, anorexia |
| 82.3 | 10 | 6 | 60 | Asthenia, anorexia | |
| 69.9 | 10 | 5 | 50 | Asthenia, anorexia | |
| 59.4 | 10 | 3 | 30 | None | |
| 50.5 | 10 | 3 | 30 | None | |
| Taxol | 44.1 | 10 | 9 | 90 | Asthenia, anorexia, syncope, dyspnea |
| 37.5 | 10 | 7 | 70 | Asthenia, anorexia, syncope, dyspnea | |
| 31.8 | 10 | 5 | 50 | Asthenia, anorexia, syncope, dyspnea | |
| 27.0 | 10 | 2 | 20 | Asthenia, anorexia, syncope, dyspnea | |
| 23.0 | 10 | 0 | 0 | Asthenia, anorexia, syncope, dyspnea |