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Therapeutic efficacy in a rat MCAO model. (a) TTC staining of brain slices (b) quantitative representation of infarct size and (c) functional outcomes assessed using a sensorimotor score. nS (native SOD1); S2p (DTSSP-cross-linked purified cl-nanozymes). Treatment was administered at the onset of reperfusion (following a 2 h ischemia) i.v. via the tail vein at a dose of 10 kU/kg and sensorimotor functions were evaluated 22 h post-reperfusion before dissecting the brains for TTC staining.
