Figure 4. Relationship between BMI or Percent Body Fat (%BF) and Gene Expression in the CHDWB study.

(A) Regression of percent body fat (%BF) on Axis 2 score in both sexes. (B) and (C) Volcano plots of significance against effect size for transcripts associated with Axes 2 with BMI (green) and with %BF (blue). The X axis is the estimated correlation between transcript abundance and the trait for each of 3913 unique genes in the 189 individuals in the cohort that are correlated with one or more axes in both Atlanta and Morocco. The dashed horizontal line is at p = 10⁻⁴: only 10 points are expected above this line, and these do not yield a clear enrichment for gene ontology classes, but the Axis analysis shows clear up-regulation of the two axes in general.