Table 2. In vivo blockade of PD-L2, but not PD-L1, results in a reduced incidence of Mf within the blood and pleural cavity.
Incidence of blood Mf | Incidence of PC Mf | |||||||
IgG | αPD-L1 | αPD-L2 | αPD-L1 + αPD-L2 | IgG | αPD-L1 | αPD-L2 | αPD-L1 + αPD-L2 | |
Exp 1 | 3/6 | 3/3 | 1/6 | 2/5 | 4/6 | 3/3 | 1/6 | 1/5 |
Exp 2 | 3/6 | 5/6 | 1/6 | 2/5 | 3/6 | 4/5 | 4/6 | 3/5 |
Exp 3 | 5/8 | 5/7 | 4/7 | 3/7 | 7/8 | 7/7 | 4/7 | 3/7 |
Total | 11/20 | 13/16 | 6/19* | 7/17* | 14/20 | 14/15 | 9/19* | 7/17* |
(55%) | (81%) | (32%) | (41%) | (70%) | (93%) | (47%) | (41%) |
Significant difference in Mf incidence driven by αPD-L2 treatment, p<0.001 (GLM using combined data from three experiments).