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. 2013 Mar 14;9(3):e1002953. doi: 10.1371/journal.pcbi.1002953

Figure 3. DHPG concentration-dependent enhancement of DSI and 2AG production.

Figure 3

(A) Experimental results replotted from Uchigashima et al. J. Neurosci. 2007. The enhancement of suppression was calculated as the change in the magnitude of DSI with DHPG application relative to the suppression without DHPG. (B) Simulation results. Mean and standard error calculated from 3 simulations repeated with different random number seeds. The enhancement of 2AG production is calculated as the ratio of mean 2AG in response to DHPG+calcium divided by 2AG in response to calcium alone. Simulations show that endocannabinoid production in the model is strongly facilitated when calcium influx into the spine and Gq coupled receptor activation are combined. This result matches experimental data in which DSI experiments show that depolarization synergizes with Gq coupled receptor activation.