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. 2013 Mar 14;9(3):e1002935. doi: 10.1371/journal.pcbi.1002935

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© 2013 Feng et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Heatmap of for the position-specific kinetic rate variance explained by sequence context suggests that 7 bases upstream and 2 bases downstream, [−7,+2], of the incorporation site are the most informative. Bases beyond this region do not provide much information about polymerase kinetics. (B) Scatter plot of the [−7,+2] context effect in whole genome amplified E. coli and M. pneumoniae (E. coli WGA-C and M. pneumoniae WGA-C2 in the Table 1) shows that context effects are highly consistent between these experiments, with a Pearson's correlation coefficient is 0.91.

Inline graphic — (A) Heatmap of for the position-specific kinetic rate variance explained by sequence context suggests that 7 bases upstream and 2 bases downstream, [−7,+2], of the incorporation site are the most informative. Bases beyond this region do not provide much information about polymerase kinetics. (B) Scatter plot of the [−7,+2] context effect in whole genome amplified E. coli and M. pneumoniae (E. coli WGA-C and M. pneumoniae WGA-C2 in the Table 1) shows that context effects are highly consistent between these experiments, with a Pearson's correlation coefficient is 0.91.