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. 2013 Mar 14;8(3):e58814. doi: 10.1371/journal.pone.0058814

Figure 1. Bassoon contains a 14-3-3 interaction interface. (A).

Figure 1

Domain structure of Bassoon with the position of the fragments Bsn28 and Bsn11 (horizontal bars) containing serine-2845 (vertical line) critical for 14-3-3η interaction are depicted. (PBH 1-10: Bassoon/ Piccolo homology domains 1-10; Zn: Zinc finger domain; cc: coiled coil domain) The deletion of exon 4 and 5 in BsnΔEx4/5 mutant mice and positions of epitopes of antibodies used in the study are depicted. (B) Alignment of the amino acid sequences of the region containing the 14-3-3 binding motif from Bassoon orthologues of different species is shown. The RSM/LpSDP 14-3-3 binding motif is bold and the critical serine residue S2845 is boxed.