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Different XRCC1 patterns are observed in KBrO3-treated cells
| Kinetics | Size | Circularity | PARP dependent | Co-localization with OGG1 | Excluded from HC | |
|---|---|---|---|---|---|---|
| SSBR | Fast (0–5′) | 0.05 μm2 | 1 | Yes | No | No |
| BER | Slow (max 3H) | 3 µm2 | 0.2 | No | Yes | Yes |
Kinetics of formation, morphology, PARP dependency, co-localization with the BER protein OGG1 or exclusion from heterochromatin (HC) domains allows to distinguish XRCC1 participation in SSBR or BER.
