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Ddk1 belongs to the PD-(D/E)XK phosphodiesterase superfamily. (A) 3D model for the PD-(D/E)XK nuclease domain of human Ddk1 (gi|14042227). Catalytic PD-(D/E)XK signature residues are shown in red, whereas other potentially important active site amino acids are denoted in green. Secondary structure elements forming the structural core of the fold are coloured yellow (β-strands) and blue (α-helices). (B) E. coli RecE (pdb|3h4r) nuclease domain (the closest homologue of known structure).
