Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2013 Jan 29;41(5):3457–3470. doi: 10.1093/nar/gkt042

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2013. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 6. — Structural models of siRNA duplex recognition by RHA. (A) Structural model of RHA full protein without C-terminal RGG motif in complex with siRNA duplex. In this model, the siRNA duplex is sandwiched between two dsRBDs in the front and D1 and D2 of RHA helicase core in the back without stereo clashes. The dsRBD domains are coloured in magenta and cyan respectively, whereas D1 and D2 are coloured in yellow and wheat, respectively. The siRNA duplex is coloured in orange. This model might represent a working model for siRNA duplex recognition and partial unwinding by the full-length RHA protein. (B) Crystal structure of A. aeolicus RNaseIII-dsRBD in complex with dsRNA (PDBID: 2EZ6).