Cluster analysis of TBP domains. Groups identified by convex clustering and their jack-knife support are as follows: DNA glycosylase group 1 (91 members, red circles, left cluster) 97%, DNA glycosylase group 2 (46 members, red circles, right cluster) 40%, TBPs and halobacterial single TBP-domain proteins (61 members including 58 TBPs and 3 halobacterial single TBP-domain proteins, green triangles) 100%, RNase HIII (33 members, yellow crosses) 100%, DNA glycosylase group 3 (18 members, blue squares) 87%, single TBP-domain protein group 1 (10 members, purple diamonds, left cluster) 100%, single TBP-domain protein group 2 (two members, purple diamonds, right cluster) 87%, ThiF-MoeZ-MoeB group (three members, orange circles) 100%, COPG group (302 members, light green inverted triangles) 78%, AP appendage group (152 members, pink Y-shapes) 73% and a number of smaller loosely associated satellite clusters associated with either the COPG or AP appendage group and coloured accordingly. Domain architectures for all clusters are depicted in Figure 6. Coloured symbols are equivalent across both figures. See ‘Materials and Methods’ section for full description of analysis and settings.