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. 2013 Feb 1;41(5):3022–3031. doi: 10.1093/nar/gkt057

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© The Author(s) 2013. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Proposed mechanism of alternative splicing regulated by the pairing between α and α′. (A) Portions of α′ can alternatively base pair to form the right shoulder of the aptamer P1 stem or form a base-paired structure with α, which is closest to the 5′ splice site S1. Mutants M1 through M6 involve the shaded nucleotide variations, and their gene expression and alternative splicing activities are presented in Figure 5. (B) Sequence alignments depicting conserved nucleotides and base-pairing potential between the α and α′ elements. Boxed nucleotides can base pair between the two regions. Overlined nucleotides in α′ form the right shoulder of the aptamer P1 stem. Nucleotides depicted in gray are different from the N. crassa sequence but they retain base pairing with the distal complementary site. Ncr, N. crassa; Cgl, Chaetomium globosum; Gze, Gibberella zeae; Fgr, Fusarium graminearum; Fve, Fusarium verticillioides; Val, Verticillium albo-atrum; Vda, Verticillium dahliae; Hca, Histoplasma capsulatum; Pbr, Paracoccidioides brasiliensis; Ure, Uncinocarpus reesii; Cim, Coccidioides immitis; Cpo, Coccidioides posadasii; Mca, Microsporum canis; Mgy, Microsporum gypseum; Ptr, Pyrenophora tritici-repentis; Sno, Stagonospora nodorum; Mgr, Magnaporthe grisea.