Figure 10. Pho-s inhibits lung metastasis of Renca cells in BALB/c mice.

(a) Schedule of treatment of Pho-s and Sunitinib. 1×10⁶ Renca cells were injected via the tail vein, and on the fourth day after the tumor implant, the treatment (i.p.) was started with Pho-s at the concentrations of 50 and 100 mg/kg/day and 10 mg/kg/day of Sunitinib and continued for 15 days. Both concentrations of Pho-s, significantly (***p<0.001) reduced both the number of lung metastasis per animal (b) and the incidence of metastasis (c), when compared to untreated mice and to treatment with Sunitinib. (d) H&E sections of lung metastasis 15 days after tumor inoculation from untreated mice and mice treated with 10 mg/kg Suntinib show the multiple metastatic foci (arrows), while in mice treated with Pho-s at both doses almost no metastatic foci can be seen. (Original magnification x20).