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. 2013 Mar 14;8(3):e58730. doi: 10.1371/journal.pone.0058730

Figure 2. AG490 inhibited the up-regulation of p-JAK2, p-STAT3 and PCNA, and attenuated cell proliferation after AA.

Figure 2

A: AG490 down-regulated the activation of JAK2/STAT3 in the AA+AG490 group on the 7th day (n = 4 anastomoses). B–D: mRNA levels of PCNA were up-regulated after AA, and inhibited markedly after treating with AG490 on the 7th day. Protein levels of PCNA were increased and peaked at the 7th day after AA, and down-regulated in AA+AG490 group (n = 4 anastomoses). E–F: Morphometry analysis of CCA on the 7th and 14th day. Quantification analysis results were illustrated by the outside radius (Ro)/inside radius (Ri) ratio. Bar = 500 µm. n = 3 anastomoses. (* p<0.05 versus AA+AG490 group (7th day); ** p<0.01 versus Sham group; ## p<0.01, §§ p<0.01; NS: no significant difference).