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. 2013 Mar 14;8(3):e58733. doi: 10.1371/journal.pone.0058733

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© 2013 Meunier et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A. Chromosome 3 haplotypes of AcB/BcA strains are displayed along with their resistance (white) or susceptibility (black) status for AOM-induced CRC (bottom strip). The B6-derived chromosomal segments are indicated in grey (2), while the A haplotypes are annotated in white (1). Arrows (↓) indicate key RCS strains delineating the minimum chromosomal interval for the Ccs3 locus. B. Detailed haplotype map of the Ccs3 locus, including delineation of the proximal and distal boundaries by high-density SNP genotyping in key informative congenic strains (AcB52, AcB60).