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. 2013 Mar 14;8(3):e58733. doi: 10.1371/journal.pone.0058733

Figure 3. Positional candidate gene analysis of the Ccs3 locus.

Figure 3

A. The Ccs3 locus contains 12 annotated transcripts, which position, direction of transcription (arrow), and position of reference SNP markers are shown. B. The position of long range amplification products used for deep sequencing of Nfκb1 is shown to scale along with the position of the 25 coding and non-coding exons of Nfκb1. The position of the 54 bp intronic deletion identified in A/J is shown. It corresponds to the loss of a direct 54 bp repeat which is present in two copies in B6 (shaded in grey), which is itself composed of a 3-repeat structure (identified by arrows above the sequence). The position of the copy number variant with respect to exon 15 of the gene is shown, together with a projection of exon 15 translated sequence on predicted protein structure. Predicted p50 and IκBγ portions of the protein are shown, along with the Rel homology domain (RHD), ankyrin-repeats (ANK), death domain (DEAD) and glycine-rich region (G) separating p50 and p105 (called IκBγ).