Table 2.
Levels of Angiogenesis-related Proteins Showing Statistically Significant Differences in Univariable Analysis
| Protein | CAV (n = 17) | No CAV (n = 16) | p |
|---|---|---|---|
| VEGF-C | 274 [63, 328] | 0 [0, 99] | 0.001 |
| Artemin | 157 [0, 579] | 0 [0, 0] | 0.002 |
| uPA | 590 [103, 1,192] | 0 [0, 272] | 0.003 |
| Vasohibin | 500 [28, 851] | 0 [0, 96] | 0.003 |
| Angiopoietin-2 | 520 [0, 799] | 0 [0, 0] | 0.004 |
| VEGF-A | 1,951 [806, 7,902] | 372 [0, 1,423] | 0.007 |
| Endothelin-1 | 434 [0, 908] | 0 [0, 116] | 0.01 |
| Thrombospondin-2 | 459 [10, 983] | 0 [0, 237] | 0.01 |
| Amphiregulin | 353 [0, 752] | 0 [0, 136] | 0.02 |
| TGF-β1 | 492 [67, 719] | 46 [0, 138] | 0.02 |
| CCL3 | 757 [37, 1,393] | 18 [0, 470] | 0.02 |
| Persephin | 328 [0, 737] | 0 [0, 33] | 0.02 |
| PF-4 | 1,066 [484, 8,840] | 84 [0, 2,548] | 0.02 |
| SerpinB5 | 704 [43, 1,358] | 0 [0, 421] | 0.02 |
| Thrombospondin-1 | 718 [0, 1,200] | 0 [0, 170] | 0.02 |
| Epidermal growth factor | 943 [0, 1,540] | 0 [0, 566] | 0.03 |
| FGF1 (acidic) | 433 [0, 661] | 0 [0, 252] | 0.04 |
| FGF2 (basic) | 290 [26, 531] | 0 [0, 117] | 0.04 |
| HBEGF | 830 [109, 1,842] | 209 [0, 816] | 0.04 |
| TYMP | 683 [44, 1,099] | 54 [0, 328] | 0.04 |
| SerpinF1 | 1,115 [188, 1,639] | 287 [0, 769] | 0.04 |
The densitometric value for each molecule is presented as the median [25th percentile, 75th percentile]. Comparisons were made using the Mann–Whitney U-test. CAV, cardiac allograft vasculopathy; FGF1, fibroblast growth factor 1; FGF2, fibroblast growth factor 2; HBEGF, heparin-binding EGF-like growth factor; TGF-β1, transforming growth factor-beta1; CCL3, chemokine (C-C motif) ligand 3; TYMP, thymidine phosphorylase; serpinB5, serpin peptidase inhibitor, clade B (ovalbumin), member 5; PF-4, platelet factor-4; serpinF1, serpin peptidase inhibitor, clade F (alpha-2 anti-plasmin, pigment epithelium-derived factor), member 1; uPA, plasminogen activator, urokinase; VEGF-A, vascular endothelial growth factor-A; VEGF-C, vascular endothelial growth factor-C.