FIGURE 1.

Topology and amino acid sequences of the N-tail and TM segments of the model proteins. A, the constructs are named with the N-tail region designated first followed by the TM segment name (i.e. the Pf3-Lep model protein contains the Pf3 N-tail and the LepTM segment). The rectangles correspond to the TM segment of a membrane protein. The TM segment of each construct is followed by residues 23–323 of Lep, where an arginine is present at position 79 of Lep following TM2. B, the amino acid sequences of the N-tail and TM segments of the model proteins Pf3-LepTM, a-aTM, a-LepTM, and Pf3-aTM.