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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: J Thorac Oncol. 2013 Apr;8(4):452–460. doi: 10.1097/JTO.0b013e3182843721

Figure 4. Radiological-histopathologic correlation of tissue invasion between CANARY based nodule assessment and consensus histopathology.

Figure 4

Examples of representative CT images with superimposed CANARY “signatures” (distinctive combinations of exemplars within one nodule) associated with nodules with varying degrees of histological invasion (%, 100 – consensus histopathology lepidic growth %) (Panel A.).

Correlation between CANARY and consensus histopathology for pulmonary nodules of the adenocarcinoma spectrum, Training Set, excluding 16 cases used to develop CANARY (n=38), Panel B. and Validation Set (n=86), Panel C. Spearman’s correlation (p<0.0001), line represents linear regression (Panels B. and C.).