Table II.
Multivariate Cox PH model, including hazard ratios and 95% confidence intervals (CI). All tumor response assessment metrics were modeled as continuous specific growth rate (SGR) from baseline.
| Variable | Hazard Ratio | 95% CI | p-value | |
|---|---|---|---|---|
| Linear Thickness Measurement Model | ||||
| Linear Thickness | (continuous, SGR) | 1.47 | [1.18, 1.84] | 0.00053 |
| Histology | Epithelioid | 1 | - | - |
| Other | 1.95 | [1.05, 3.65] | 0.036 | |
| Dyspnea | No | 1 | - | - |
| Yes | 2.46 | [1.09, 5.55] | 0.030 | |
| ECOG Performance Status | 0 | 1 | - | - |
| 1 or 2 | 1.47 | [0.83, 2.61] | 0.099 | |
|
Disease Volume Measurement Model | ||||
| Disease Volume | (continuous, SGR) | 1.33 | [1.13, 1.58] | 0.00090 |
| Histology | Epithelioid | 1 | - | - |
| Other | 2.04 | [1.10, 3.79] | 0.023 | |
| Dyspnea | No | 1 | - | - |
| Yes | 2.81 | [1.19, 6.61] | 0.018 | |
| ECOG Performance Status | 0 | 1 | - | - |
| 1 or 2 | 1.54 | [0.89, 2.67] | 0.12 | |
|
Normalized Lung Volume Measurement Model | ||||
| Normalized Lung Volume | (continuous, SGR) | 0.76 | [0.64, 0.91] | 0.0033 |
| Histology | Epithelioid | 1 | - | - |
| Other | 2.38 | [1.30, 4.34] | 0.0050 | |
| Dyspnea | No | 1 | - | - |
| Yes | 2.15 | [0.98, 4.74] | 0.056 | |
| ECOG Performance Status | 0 | 1 | - | - |
| 1 or 2 | 1.58 | [0.92, 2.73] | 0.099 | |