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. Author manuscript; available in PMC: 2013 Mar 15.
Published in final edited form as: Postgrad Med. 2011 Sep;123(5):39–49. doi: 10.3810/pgm.2011.09.2458

Figure 3.

Figure 3

Differences between glucose and fructose metabolism. Glucose is phosphorylated by glucokinase into glucose-6-phosphate, which is isomerized to fructose-6-phosphate as part of the glycolysis for ATP production in the mitochondria and fat accumulation. Excessive fructose-6-phosphate generation activates GKRP for glucokinase inhibition. Unlike glucose, fructose metabolism is not negatively regulated. Therefore, fructose readily induces intracellular phosphate and ATP depletion during its metabolism by fructokinase. The decrease in intracellular phosphate that occurs during fructose metabolism also results in the stimulation of AMPD, which converts AMP to IMP and uric acid.

Abbreviations: AMP, adenosine monophosphate; AMPD, adenosine monophosphate deaminase; ATP, adenosine triphosphate; GKRP, glucokinase regulatory protein; IMP, inosine monophosphate.