Table 3.

Comparison of Quantitative Real-Time Polymerase Chain Reaction (qRT-PCR) Values With Prior Microarray Expression for Eight Candidate Genes in Preeclampsia Chorionic Villus Sampling (CVS) Specimens

			qRT-PCRc
Gene Symbol	Microarraya	Trendb	PE (n = 4)	C (n = 8)	AS (n = 24)	p Value	Trendb
S100A8	13.19	↑	Undetermined	Undetermined	Undetermined	—	—
SEMA3C	−8.42	↓	15.50 ± 19.86	22.25 ± 26.28	17.75 ± 29.80	0.50	↓
CFH	−8.45	↓	9.25 ± 19.28	21.14 ± 24.25	18.54 ± 28.14	0.16	↓
FSTL3	−10.05	↓	6.00 ± 19.86	20.06 ± 26.28	20.06 ± 29.80	0.04d	↓
IGFBP1	−10.35	↓	12.38 ± 19.47	24.75 ± 25.76	17.44 ± 29.20	0.10	↓
EPAS1	−15.34	↓	16.00 ± 19.86	16.38 ± 26.28	19.63 ± 29.80	0.68	↓/=
PAEP	−15.64	↓	18.63 ± 19.28	27.38 ± 25.45	14.63 ± 28.77	0.01d	↓/=
MMP12	−17.18	↓	11.50 ± 19.87	22.63 ± 26.28	18.29 ± 29.80	0.23	↓

Note. AS = additional control samples; C = control samples; PE = preeclampsia samples.

^aExpression level by J5 score is a gene-specific ratio between the mean difference in expression intensity of a gene in two groups to the average mean group difference of all genes for the entire data set, as previously reported (Founds et al., 2009).

^bUp-(↑) or down-(↓) regulation or about the same (=) in the PE group as compared to the C or AS group or both. The microarray study included only PE and C groups.

^cWilcoxon mean score ± SD.

^dSignificant difference, p ≤ .05.