Table 1.
Association results for rs5945572 on Xp11.22 and prostate cancer in Iceland, The Netherlands, Spain, Sweden and the United States
| Study population (cases/controls) |
Frequency | |||
|---|---|---|---|---|
| Variant (allele) | Cases | Controls | OR (95% c.i.) | P value |
| Iceland (1,833/21,372)a | ||||
| rs5945572 (A) | 0.414 | 0.368 | 1.21 (1.09 – 1.34) | 3.36 × 10−4 |
| Holland (991/2,021) | ||||
| rs5945572 (A) | 0.390 | 0.347 | 1.20 (1.04 – 1.39) | 0.015 |
| Spain (539/1,594) | ||||
| rs5945572 (A) | 0.432 | 0.364 | 1.33 (1.10 – 1.61) | 3.20 × 10−3 |
| Sweden (2,865/1,722) | ||||
| rs5945572 (A) | 0.421 | 0.379 | 1.19 (1.05 – 1.34) | 4.84 × 10−3 |
| Baltimore, Maryland (1,516/554) | ||||
| rs5945572 (A) | 0.397 | 0.334 | 1.31 (1.07 – 1.60) | 8.39 × 10−3 |
| Chicago, Illinois (656/503) | ||||
| rs5945572 (A) | 0.402 | 0.354 | 1.23 (0.98 – 1.54) | 0.072 |
| Nashville, Tennessee (526/612) | ||||
| rs5945572 (A) | 0.392 | 0.353 | 1.18 (0.93 – 1.50) | 0.18 |
| Rochester, Minnesota (1,128/500)b | ||||
| rs5945572 (A) | 0.381 | 0.306 | 1.40 (1.11 – 1.76) | 4.39 ×10−3 |
| All excluding Iceland (8,221/7,506)c | ||||
| rs5945572 (A) | – | 0.348 | 1.24 (1.16 – 1.33) | 2.57 × 10−10 |
| All combined (10,054/28,879)c | ||||
| rs5945572 (A) | – | 0.351 | 1.23 (1.16 – 1.30) | 3.95 × 10−13 |
All P values shown are two-sided. Shown are the corresponding numbers of cases and controls (n), allelic frequencies of variants in affected and control individuals, the allelic odds ratio (OR) with 95% confidence interval (95% c.i.) and P values. For additional information on assays and frequencies, see Supplementary Tables 4 and 5 online.
Results presented for Iceland were adjusted for relatedness using a method of genomic control (see Supplementary Methods).
Results presented for the Rochester study group were adjusted for relatedness by applying a pedigree correction factor (see Supplementary Methods).
For the combined study populations, the reported control frequency was the average, unweighted control frequency of the individual populations, whereas the OR and the P value were estimated using the Mantel-Haenszel model.