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Model for the regulation of T cell function by Egr-1, 2, 3 and NAB2. We propose that Egr-3 and Egr-2 are important mediators of the negative regulatory program downstream of isolated NF-AT signaling. Our data suggest that Egr-2 is up-regulated by Egr-3. Egr-2 and Egr-3 inhibit T cell function by both promoting the up-regulation of negative regulators such as Cbl-b and by inhibiting the expression of the T cell activators Egr-1 and NAB2.
